J-SUPPORT1605
Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery: a randomized, double-blind, placebo-controlled trial
| Study Title | Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery: a randomized, double-blind, placebo-controlled trial |
|---|---|
| Principal Investigator/Study Manager/Mentor | Ken Shimizu/Saho Wada/Takuhiro Yamaguchi |
| Condition | Patients scheduled to undergo highly invasive surgery |
| UMIN Clinical Trials Registry | UMIN000027561 |
| Funding Source | Founded Study |
| Protocol Paper | Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery. J-SUPPORT 1605 (ProD Study): study protocol for a randomized controlled trial. Trials. 2019 Feb 8;20(1):110. doi: 10.1186/s13063-019-3202-1. PMID: 30736826 https://www.ncbi.nlm.nih.gov/pubmed/30736826 |
| Publication |
Yokukansan for Treatment of Preoperative Anxiety and Prevention of Postoperative Delirium in Cancer Patients Undergoing Highly Invasive Surgery. J-SUPPORT 1605 (ProD Study): A Randomized, Double-Blind, Placebo-Controlled Trial.
[Secondary Analysis Paper] Prevention of delirium with agitation by yokukansan in older adults after cancer surgery. Jpn J Clin Oncol. 2022 Nov 3;52(11):1276-1281. doi: 10.1093/jjco/hyac123. PMID: 35907781 https://pubmed.ncbi.nlm.nih.gov/35907781/
[Accompanying Research Paper] Metabolome Profiling of Yokukansan in Preventing Postoperative Delirium in Elderly Cancer Patients: A Reverse Translational Study Psychiatry Clin Neurosci. 2025 Aug 5. doi: 10.1111/pcn.13875. Online ahead of print. |
| Spreading effect |